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Publications (see in Pubmed)
Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation Tcherkezian, J., Brittis, P.A., Thomas, F., Roux, P.P., Flanagan, J.G. Cell 141, 632-644 (2010)
mTORC1-Activated S6K1 Phosphorylates Rictor on Threonine 1135 and Regulates mTORC2 Signaling Mol. Cell. Biol. 30, 908-21 (2010)
Regulation of mTOR complex 1 (mTORC1) by Raptor S863 and multi-site phosphorylation Foster, K.G., Acosta-Jaquez, H.A., Romeo, Y., Ekim, B., Soliman, G.A., Carriere, A., Roux, P.P., Ballif, B.A., Fingar, D.C. J. Biol. Chem. 285, 80-94 (2010)
Y-box binding protein-1 (YB-1) serine 102 is a downstream target of p90 ribosomal S6 kinase (RSK) in basal-like breast cancer cells Stratford, A.L., Fry, C.J., Desilets, C., Davies, A.H., Cho, Y.Y., Li, Y., Dong, Z., Berquin, I.M., Roux, P.P., Dunn, S.E.
Breast Cancer Res. 10, R99 (2008) Choo, Y.A., Yoon, S., Kim, S.G., Roux, P.P., Blenis, J. Proc. Natl Acad. Sci. USA 105, 17414-9 (2008)
Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated Raptor phosphorylation Carriere, A., Cargnello, M., Julien, L.-A., Gao, H., Bonneil, E., Thibault, P., Roux, P.P. Curr. Biol. 18, 1269-77 (2008) See comment in Nature Reviews Cancer (2008) 8: 739 and in Nature Signaling Gateway Update, Oct 2008
The RSK factors of activating the Ras/MAPK signaling pathway Carriere, A., Ray, H., Blenis, J., Roux, P.P. Frontiers in Bioscience 13, 4258-75 (2008)
RSK4 Roux, P.P. UCSD-Nature Molecule Pages (doi:10.1038/mp.a002102.01)(2007)
Rsk3 Roux, P.P. UCSD-Nature Molecule Pages (doi:10.1038/mp.a002101.01)(2007)
Ras/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation Roux, P.P., Shahbazian, D., Vu, H., Holz, M.K., Cohen, M.S., Taunton, J., Sonenberg. N., Blenis, J. J. Biol. Chem. 282, 14056-64 (2007)
Rsk1 Roux, P.P. UCSD-Nature Molecule Pages (doi:10.1038/mp.a002099.01)(2007)
Mind the GAP: Wnt Steps onto the mTORC1 Train Choo, A.Y., Roux, P.P., Blenis, J. Cell 126, 8-10 (2006)
The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity Shahbazian, D., Roux, P.P., Mieulet, V., Cohen, M.S., Raught, B., Taunton, J., Hershey, J.W.B., Blenis, J., Pende, M., Sonenberg, N. EMBO J. 25, 2781-91 (2006)
The proapoptotic tumor suppressor DAP kinase is a target of RSK-mediated survival signaling Anjum, R., Roux, P.P., Ballif, B.A., Gygi, S.P., Blenis, J. Curr. Biol. 15, 1762-67 (2005)
Quantitative and temporal phosphorylation profiling of the ERK-RSK signaling cassette and its target the tuberous sclerosis complex (TSC) tumor suppressor proteins Ballif, B.A.,* Roux, P.P.,* Gerber, S.A., MacKeigan, J.P., Blenis, J., Gygi, S.P. * Co-First authors Proc. Natl Acad. Sci. USA 102, 667-72 (2005)
Tumor promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via RSK Roux, P.P., Ballif, B.A., Anjum, R., Gygi, S.P., Blenis, J. Proc. Natl Acad. Sci. USA 101, 13489-94 (2004)
The ERK and p38 MAPK-activated protein kinases (MKs): a family of protein kinases with diverse biological functions Roux, P.P., Blenis, J. Microbiol. Mol. Biol. Rev. 68, 320-44 (2004)
Protein kinase A activation promotes plasma membrane insertion of DCC from an intracellular pool: a novel mechanism regulating commissural axon extension Bouchard, J.-F., Moore, S.W., Tritsch, N.X., Roux, P.P., Shekarabi, M., Barker, P.A., and Kennedy, T.E. J. Neurosci. 24, 3040-50 (2004)
Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates ERK docking and RSK activity Roux, P.P., Richards, S.A., Blenis, J. Mol. Cell. Biol. 23:4796-804 (2003)
Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb Tee, A.R., Manning, B.D., Roux, P.P., Cantley, L.C., Blenis, J. Curr. Biol. 13, 1259-68 (2003)
K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK Roux, P.P., Dorval, G, Boudreau, M., Angers-Loustau, A., Morris, S.J., Makkerh, J., Barker, P.A. J. Biol. Chem. 277, 49473-80 (2002)
Neurotrophin signaling through the p75 neurotrophin receptor Roux, P.P., Barker, P.A. Prog. Neurobiol. 67, 203-33 (2002)
The p75 neurotrophin receptor (p75NTR) activates Akt (Protein kinase B) through a Phosphatidylinositol 3-kinase-dependent pathway Roux, P.P., Bhakar, A.L., Kennedy, T.E., Barker, P.A. J. Biol. Chem. 276, 23097-104 (2001)
Activation of transcription factors NF-kappaB and NF-IL-6 by human immunodeficiency virus type 1 protein R (Vpr) induces interleukin-8 expression Roux, P., Alfieri, C., Hrimech, M., Cohen, E.A., Tanner, J.E. J. Virol. 74, 4658-65 (2000)
NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor dependent apoptosis Salehi, A.H., Roux, P.P., Kubu, C.J., Zeindler, C., Bhakar, A., Tannis, L.-L., Verdi, J.M., Barker, P.A. Neuron 27, 279-88 (2000)
p75 neurotrophin receptor expression is induced in apoptotic neurons after seizure Roux, P.P., Colicos, M.A., Barker, P.A., Kennedy, T.E. J. Neurosci. 19, 6887-96 (1999)
The p75 neurotrophin receptor alters TNF-mediated NF-kappaB activity in cell types which show no direct p75NTR-mediated NF-kappaB activation Bhakar, A.L., Roux, P.P., Lachance, C., Kryl, D., Zeindler, C., Barker, P.A. J. Biol. Chem. 274, 21443-9 (1999)
Increased apoptosis, changes in intracellular Ca++ and functional alterations in lymphocytes and macrophages after in vitro exposure to static magnetic fields Flipo, D., Fournier, M., Benquet, C., Roux, P., Le Boulaire, C., Pinsky, C., LaBella, F.S., Krzystyniak, K. J. Toxicol. Environm. Health 54, 63-76 (1998)
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